Figure 4.

Dynamics of epithelium thickness and dynamics of tissue stratification. Three cases are plotted: 1), rapid uptake of A and G in the stroma, with the intraepithelial binding with F; 2), slow uptake of A and G in the stroma, with the intraepithelial binding with F; and 3), rapid uptake of A and G in the stroma, without the intraepithelial binding with F. These cases are referred to in the figures as cases 1, 2, and 3 (and in panels A and B they are distinguished by colors green, red, and blue, respectively). The corresponding parameter sets are listed in Table S1 and Table S2. (A) Time versus the epithelium thickness (z_max) normalized by the steady-state thickness (z_ss). (B) Time versus the stem cell stratification measured by SF. (C) Distribution of cells for case 1. (D) Distribution of cells for case 2. (E) Distribution of cells for case 3.