Table 4.
Selected published GFR results from cats with naturally-occurring or clinically relevant induced diseases
| Disease condition | Marker | Number of cats | Method | GFR resultsa | Reference |
|---|---|---|---|---|---|
| Neoplasia | |||||
| Solid tumors (carcinomas and sarcomas) | 99mTc-DTPA | 10 | CLplasma | 2.4 (0.9) | Bailey et al., 2004 |
| Renal disease | |||||
| Polycystic kidney disease | 99mTc-DTPA | 5 | Renal scintigraphy | 2.7 (0.3) | Reichle et al., 2002 |
| Polycystic kidney disease | 99mTc-DTPA | 5 | CLplasma | 3.1 (1.0) | Reichle et al., 2002 |
| Allograft rejection | 99mTc-DTPA | 8 | Renal Scintigraphy | 0.87 (0.08) | Halling et al., 2003 |
| Chronic renal failure (IRIS CKD stage 2–4) | endogenous creatinine | 12 | CLurine | 0.789 (0.407) | Deguchi et al., 1997 |
| Endocrine disease | |||||
| Untreated hyperthyroidism (naturally-occurring) | Iohexol | 12 | CLplasma | 3.83 (1.82) | Becker et al., 2000 |
| Untreated hyperthyroidism (naturally-occurring) | Inulin | 24 | CLplasma | 3.79 (1.3) | Boag et al., 2007 |
| Untreated hyperthyroidism (naturally-occurring) | Exo-iohexol | 21 | CLplasma | 3.3 (1.2) | van Hoek et al., 2009 |
| Methimazole-controlled (normalized TT4) hyperthyroidism | Iohexol | 12 | CLplasma | 2.02 (0.81) | Becker et al., 2000 |
| 1 month post 131I treatment of hyperthyroidism | Inulin | 24 | CLplasma | 2.41 (0.83) | Boag et al., 2007 |
| 1 month post 131I treatment of hyperthyroidism | Exo-iohexol | 21 | CLplasma | 2.0 (0.8) | van Hoek et al., 2009 |
| 6 months post 131I treatment of hyperthyroidism | Inulin | 24 | CLplasma | 2.29 (0.98) | Boag et al., 2007 |
| 6 months post 131I treatment of hyperthyroidism | Exo-iohexol | 21 | CLplasma | 1.6 (0.6) | van Hoek et al., 2009 |
| Drug effects in healthy cats | |||||
| Following 4 days of meloxicam | Iohexol | 6 | CLplasma | 3.31 +/−0.27 | Goodman et al., 2009 |
IRIS, International Renal Interest Society; CKD, chronic kidney disease; TT4, serum total thyroxine; CLplasma, plasma clearance
a
Results reported as mL/min/kg, mean (standard deviation)