Table 3.
Correlations among MZ and DZ twins and heritability estimations for renal function and inflammatory markers
| Trait | MZ | DZ | a2 (95% CI) | c2 (95% CI) | e2 (95% CI) | |
|---|---|---|---|---|---|---|
| eGFR | Unadjusted | 0.50 | 0.31 | 0.51 (0.39–0.61) | − | 0.49 (0.39–0.61) |
| Adjusted la | 0.50 (0.38–0.60) | − | 0.50 (0.40–0.62) | |||
| Adjusted 2b | 0.48 (0.36–0.59) | − | 0.52 (0.41–0.64) | |||
| IL-6R | Unadjusted | 0.94 | 0.59 | 0.53 (0.32–0.84) | 0.39 (0.08–0.60) | 0.08 (0.06–0.11) |
| Adjusted la | 0.68 (0.40–0.89) | 0.18 (0.00–0.46) | 0.14 (0.10–0.20) | |||
| Adjusted 2b | 0.68 (0.39–0.89) | 0.18 (0.00–0.46) | 0.14 (0.11–0.20) | |||
| TNF-aR | Unadjusted | 0.64 | 0.25 | 0.63 (0.50–0.72) | − | 0.37 (0.28–0.50) |
| Adjusted la | 0.51 (0.36–0.63) | − | 0.49 (0.37–0.64) | |||
| Adjusted 2b | 0.51 (0.36–0.63) | − | 0.49 (0.37–0.64) | |||
| ICAM | Unadjusted | 0.58 | 0.10 | 0.55 (0.43–0.65) | − | 0.45 (0.35–0.57) |
| Adjusted la | 0.51 (0.39–0.61) | − | 0.49 (0.39–0.61) | |||
| Adjusted 2b | 0.50 (0.38–0.60) | − | 0.50 (0.40–0.62) | |||
| P-selectin | Unadjusted | 0.76 | 0.41 | 0.78 (0.71–0.83) | − | 0.22 (0.17–0.29) |
| Adjusted la | 0.76 (0.69–0.82) | − | 0.24 (0.18–0.31) | |||
| Adjusted 2b | 0.76 (0.69–0.81) | − | 0.24 (0.19–0.31) | |||
a2 = Genetic component (heritability); c2 = common environmental component; e2 = individual environmental component.
a
Adjusted for age, race, BMI, current smoking, diabetes, hypertension, coronary artery disease and medications (aspirin, p-block-ers, statins and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker).
b
Additionally adjusted for major depressive disorder and posttraumatic stress disorders.