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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Arthritis Rheum. 2010 Nov;62(11):3161–3172. doi: 10.1002/art.27638

Figure 2. Estimation of time-to-diagnosis of future rheumatoid arthritis (RA) by age and cytokine/chemokine counts in subjects with autoantibody positivity highly specific for future RA.

Figure 2

This figure represents the results from regression modeling of the outcome time-to-diagnosis of future RA, based on predictor variables of age-at-diagnosis (by decade) and cytokine/chemokine count (p-value for model <0.01). Pre-diagnosis RA case samples included to develop this model were those that were positive for the highly RA-specific (>96%) autoantibodies: anti-CCP and/or 2 or more rheumatoid factor isotypes (N=54 cases with 101 pre-RA diagnosis samples). For example, from this model, in a case diagnosed with RA between ages 50-59, a sample with a cytokine/chemokine count of 10 would be ~4 years prior-to-diagnosis, while for the same cytokine/chemokine count, a sample from an individual in the 20-29 age-group would be ~1 year prior-to-diagnosis. Model: Years to Diagnosis = −2.3861 - 1.0122 × (Decade*) + 0.1782 × (Cytokine/Chemokine count) *Decade 20-29 coded as 0, 30-39 coded as 1, etc.