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. Author manuscript; available in PMC: 2010 Nov 14.
Published in final edited form as: J Alzheimers Dis. 2009;17(2):281–294. doi: 10.3233/JAD-2009-1037

Figure 4. Visualization by EM of the Aβ (1–42) peptide aggregation process in the presence of HtrA2.

Figure 4

Reaction mixtures containing Aβ (1–42) alone or in the presence of HtrA2 or HSA were incubated at 37 °C. At selected times aliquots of A) Aβ (1–42) alone, B) Aβ (1–42) + HtrA2 and C) Aβ (1–42) + HSA were deposited on continuous carbon grids and negatively stained. Samples were imaged under low-dose conditions at a nominal magnification of 10,000× (larger area on micrograph) and 25,000× (boxed in region on micrograph).