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PKR-VAI interaction parameters derived from ITC analysis.
| [Mg2+] mM | Model | Kd1 (nM) |
N1 | ΔH1 (kcal/mol) |
ΔS1 (cal/mol) |
ΔG1 (kcal/mol) |
Kd2 (nM) |
N2 | ΔH2 (kcal/mol) |
ΔS2 (cal/mol) |
ΔG2 (kcal/mol) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | R + P ↔ RP RP + P ↔ RP2 |
10±7 | 0.68±0.02 | −15.9±0.5 | −17.7 | −10.8 | 794±367 | 1.34±0.10 | −7.6±1.1 | 2.1 | −8.2 |
| 5 | R + P ↔ RP | 667±125 | 1.12±0.04 | −13.2±0.5 | −16.9 | −8.3 | -- | -- | -- | -- | -- |
Parameters obtained by global nonlinear least squares analysis using ORIGIN version 5.0 software.
