Figure 1.

JIL-1 regulates dosage compensation at the white locus in males. (A) The ratio of male/female eye pigment levels in an allelic series of JIL-1 hypomorphs (comprised of the alleles JIL-1^z28, JIL-1^z60, JIL-1^h9, JIL-1^z2) in a w^a mutant background. In w^a flies a copia retrotransposon causes a general reduction of pigment level in both sexes without interfering with the dosage compensation process. The decrease in male/female eye pigment ratios correlates directly with the severity of the JIL-1 hypomorphic alleles. (B) In w^e mutant flies there is no dosage compensation due to a pogo element insertion. In this mutant background there is no significant effect of JIL-1 hypomorphic alleles on male/female eye pigment ratios. Each histogram represents the average male/female pigment ratio from sets of OD₃₆₅ measurements from 10 pooled fly heads with S.D. The average male/female pigment ratio in JIL-1 mutants were compared to that in a wild-type JIL-1 background using a Student’s t-test.