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. Author manuscript; available in PMC: 2012 Sep 1.

Published in final edited form as: Clin Microbiol Infect. 2010 Jul 15;17(9):1332–1335. doi: 10.1111/j.1469-0691.2010.03313.x

Table 2.

IC₅₀ values of plaque-purified variants with an NA substitution

Virus	Amino acid substitution in:			IC₅₀ value, nmol/l (fold-change^a)
Virus	NA	HA1	HA2	Oseltamivir	Zanamivir
B/Yokohama/UT2119/2005	-^b	-	-	72.5	10.3
PP-P15-CK-ZV	Asp198Asn	-	-	218.0 (3.0-fold)	50.5 (4.9-fold)
PP-P20-CK-ZV	Asp198Asn	-	Arg65Gly	235.4 (3.2-fold)	59.4 (5.8-fold)
PP-P20-ST6-OV	Ile222Thr	Ile307Thr	-	523.3 (7.2-fold)	21.6 (2.1-fold)

^a

Fold-change was calculated based on the IC₅₀ value of the parent B/Yokohama/UT2119/2005 virus.

^b

not applicable.