Table 3.

Adjusted hazard ratios for hypertension after age 40, coronary heart disease, and stroke between pregnancy groups^a

	FBPP participants									GENOA sub-sample
	Hypertension (after age 40) (n = 3093)b			CHD (n = 4720)b			Stroke (n = 4726)b			Hypertension (after age 40) (n = 1288)b			CHD (n = 1741)b			Stroke (n = 1744)b
	HRc	95% CI	P	HRd	95% CI	P	HRd	95% CI	P	HRe	95% CI	P	HRf	95% CI	P	HRb	95% CI	P
Normotensive vs. nulliparous	0.88	0.73–1.08	0.22	1.02	0.60–1.75	0.94	0.55	0.31–1.00	0.050	0.78	0.59–1.04	0.095	0.84	0.39–1.82	0.67	0.61	0.27–1.40	0.24
Hypertensive vs. normotensive	1.53	1.25–1.87	<0.001	1.14	0.78–1.68	0.50	1.86	1.16–2.98	0.010	1.88	1.49–2.39	<0.001	0.65	0.32–1.30	0.22	2.10	1.19–3.71	0.010

CHD, coronary heart disease; CVD, cardiovascular disease.

^aExpressed as hazard ratios (HRs) with 95% confidence intervals (CIs) from Cox proportional hazards models fit using custom software to account for potential correlation among women within sibships.

^bDue to missing data, sample sizes are smaller than the total number of 4782 and 1754 women in the Family Blood Pressure Program (FBPP) and Genetic Epidemiology Network of Arteriopathy (GENOA) cohorts, respectively.

^cModel A adjusted for network, race, family history of CVD, smoking, BMI, education, and diabetes (time-dependent).

^dModel B adjusted for network, race, family history of CVD, smoking, BMI, education, diabetes mellitus (time-dependent), and hypertension (time-dependent).

^eModel C adjusted for race, family history of CVD, smoking, dyslipidemia, and diabetes (time-dependent).

^fModel D adjusted for race, family history of CVD, smoking, dyslipidemia, diabetes mellitus (time-dependent), and hypertension (time-dependent).