Table 3.
Multivariate analyses of risk factors for developing cardiac conditions by years of diagnosis for patients with non-small-cell lung cancer
| Adjusted model | Hazard ratio (95% confidence interval) | ||
| 1991–1995 | 1996–1999 | 2000–2002 | |
| Ischemic heart disease | |||
| No treatment | 1.00 | 1.00 | 1.00 |
| Chemotherapy-only | 1.31 (1.02–1.68) | 1.22 (0.93–1.60) | 1.26 (1.04–1.53) |
| Radiation therapy-only | 0.89 (0.75–1.06) | 0.98 (0.77–1.23) | 0.80 (0.65–0.97) |
| Chemoradiation | 0.98 (0.79–1.21) | 1.24 (0.97–1.59) | 1.14 (0.93–1.39) |
| Cardiomyopathy | |||
| No treatment | 1.00 | 1.00 | 1.00 |
| Chemotherapy-only | 1.19 (0.53–2.69) | 1.63 (0.62–4.32) | 0.37 (0.15–0.93) |
| Radiation therapy-only | 0.58 (0.23–1.48) | 0.63 (0.17–2.35) | 0.29 (0.11–0.79) |
| Chemoradiation | 0.53 (0.14–2.02) | 0.84 (0.15–4.67) | 0.29 (0.08–1.09) |
| Conduction disorders | |||
| No treatment | 1.00 | 1.00 | 1.00 |
| Chemotherapy-only | 0.67 (0.24–1.84) | 1.21 (0.56–2.63) | 1.02 (0.54–1.93) |
| Radiation therapy-only | 1.32 (0.86–2.03) | 0.92 (0.51–1.66) | 0.80 (0.46–1.38) |
| Chemoradiation | 0.90 (0.48–1.69) | 1.45 (0.80–2.62) | 1.59 (0.98–2.58) |
| Cardiac dysfunction | |||
| No treatment | 1.00 | 1.00 | 1.00 |
| Chemotherapy-only | 1.54 (1.15–2.05) | 1.55 (1.16–2.06) | 1.63 (1.30–2.05) |
| Radiation therapy-only | 1.63 (1.20–2.20) | 1.48 (1.05–2.07 | 1.65 (1.24–2.19) |
| Chemoradiation | 2.28 (1.56–3.33) | 2.36 (1.57–3.57) | 2.53 (1.81–3.54) |
| Heart failure | |||
| No treatment | 1.00 | 1.00 | 1.00 |
| Chemotherapy-only | 1.44 (1.10–1.89) | 1.42 (1.05–1.93) | 1.13 (0.89–1.43) |
| Radiation therapy-only | 1.08 (0.93–1.26) | 1.19 (0.96–1.48) | 0.97 (0.79–1.18) |
| Chemoradiation | 1.13 (0.92–1.38) | 1.29 (1.02–1.62) | 1.17 (0.97–1.42) |
See Table 2 for variables adjusted for in the analyses. Statistically significant hazard ratios are in bold.