FIGURE 3.
Mean (±SEM) insulin sensitivity (n = 22). After 12 wk of aerobic exercise combined with either a low–glycemic index diet (LoGIX; gray bars) or a high–glycemic index diet (HiGIX; black bars), changes in glucose kinetics were measured during 40 mU · m−2 · min−1 hyperinsulinemic euglycemic clamps. Values represent poststudy minus prestudy changes (Δ) in glucose kinetics. Basal rates of glucose appearance (Ra) decreased significantly (A) [basal Ra of hepatic glucose production (Basal Ra HGP); main effect of time, P < 0.05 (2-factor ANOVA)], whereas insulin-suppression of HGP (Insulin-Suppressed Ra HGP) increased after the intervention (B) (P < 0.05). Rates of glucose disappearance during hyperinsulinemia (Insulin-Stimulated Rd) increased significantly (C) (P < 0.05). No significant differences between LoGIX and HiGIX groups were observed (P = NS).