TABLE 2.
Plasma concentrations of lipid peroxidation and serum antioxidants according to mean alternate Mediterranean Diet Score (aMED) across the menstrual cycle in premenopausal women (n = 259)1
| Mean aMED |
||||||
| Total cohort | 0–2 | 2.01–3 | 3.01–4 | 4.01–9 | P value2 | |
| No. of cycles | 509 | 128 | 187 | 126 | 68 | |
| Lipid peroxidation | ||||||
| 8-iso-PGF2α (pg/mL) | 46.2 (36.9, 59.0)3 | 52.0 (39.6, 68.6) | 46.5 (37.0, 58.7) | 45.5 (37.3, 57.2) | 39.3 (33.0, 47.5) | 0.01 |
| 9-HODE (μmol/L) | 0.15 (0.09, 0.24) | 0.16 (0.09, 0.26) | 0.15 (0.09, 0.25) | 0.14 (0.10, 0.23) | 0.12 (0.08, 0.21) | <0.001 |
| TBARS (nmol/mL) | 0.85 (0.72, 1.00) | 0.81 (0.70, 0.98) | 0.87 (0.74, 1.02) | 0.84 (0.73, 0.99) | 0.87 (0.75, 0.99) | 0.15 |
| Antioxidants | ||||||
| α-Tocopherol (μg/mL) | 8.0 (6.8, 9.3) | 7.5 (6.6, 8.8) | 7.9 (6.7, 9.1) | 8.2 (7.0, 9.6) | 8.3 (7.2, 10.3) | 0.19 |
| δ-Tocopherol (μg/mL) | 0.15 (0.11, 0.19) | 0.14 (0.11, 0.19) | 0.15 (0.12, 0.20) | 0.14 (0.11, 0.19) | 0.14 (0.10, 0.18) | 0.80 |
| γ-Tocopherol (μg/mL) | 1.7 (1.4, 2.2) | 1.8 (1.5, 2.2) | 1.8 (1.4, 2.2) | 1.6 (1.2, 2.0) | 1.5 (1.1, 2.0) | 0.65 |
| Retinol (μg/mL) | 0.37 (0.32, 0.42) | 0.36 (0.30, 0.42) | 0.36 (0.32, 0.41) | 0.38 (0.32, 0.43) | 0.38 (0.34, 0.43) | 0.85 |
| Ascorbic acid4 (mg/dL) | 1.7 (1.4, 2.0) | 1.6 (1.3, 1.9) | 1.6 (1.4, 2.0) | 1.8 (1.5, 2.1) | 1.9 (1.6, 2.3) | 0.04 |
1
8-iso-PGF2α, F2-isoprostane; 9-HODE, 9-hydroxyoctadecadieneoic acid; TBARS, thiobarbituric acid reactive substances.
2
Two-sided P values were calculated by using generalized linear mixed models. All comparisons take repeated measures and correlations between cycles into account.
3
Median; 25th, 75th percentile in parentheses (all such values).
4
Ascorbic acid was measured in plasma.