Table 1.

Blood urea nitrogen (BUN), urine protein/creatinine concentration ratio (Prot/creat) and plasma total cholesterol (chol), triglyceride and HDL-cholesterol concentrations and paraoxonase activity in the wild-type (control) and untreated and D-4F-treated apoE^−/− mice

	Control	ApoE−/−	ApoE−/− + 4F
BUN (mg/dL)	25.5 ± 1.8	28.1 ± 0.1	26.1 ± 0.4
Urine Prot/creat	3.1 ± 0.3	4.7 ± 0.04*	2.4 ± 0.2****
chol (mg/dL)	87.5 ± 6.8	573.6 ± 26.6**	522.4 ± 28.8
triglyceride (mg/dL)	70.1 ± 9.0	166.4 ± 10.4**	150.6 ± 12.3
HDL-chol (mg/dL)	46.2 ± 4.2	27.8 ± 0.6*	32 ± 1.4***
PON activity	71.1 ± 5.1	24.2 ± 0.9**	31.4 ± 1.9***

n = 6 in each group.

^*P < 0.05 apoE^−/− vs CTL mice.

^**P < 0.005 apoE^−/− vs CTL mice.

^***P < 0.05 D-4F-treated vs untreated apoE^−/− mice.

^****P < 0.005 D-4F-treated vs untreated apoE^−/− mice.