Table 2.
Summary estimates of effect of H pylori eradication on iron deficiency anaemia in subgroup analyses
| Summary estimate (WMD) | 95% CI | Heterogeneity (х2) | p Value* | |
| Haemoglobin (g/l) | ||||
| Age | ||||
| Children | 11.77 | 2.40 to 21.15 | 30.48 | <0.0001 |
| Adult | 15.11 | 7.87 to 22.35 | 0.43 | 0.51 |
| Treatment | ||||
| Bismuth | 20.73 | 7.85 to 33.61 | 1.48 | 0.02 |
| PPI | 10.42 | 2.75 to 18.08 | 27.63 | <0.0001 |
| Degree of anaemia | ||||
| Moderate anaemia | 9.13 | −0.40 to 18.66 | 26.20 | <0.0001 |
| Marked anaemia | 16.92 | 10.37 to 23.46 | 2.42 | 0.49 |
| Time period | ||||
| 4 weeks | 13.75 | 8.84 to 18.65 | 1.11 | 0.57 |
| 8 weeks | 15.47 | 8.98 to 21.97 | 10.76 | 0.03 |
| Serum ferritin (μg/l) | ||||
| Age | ||||
| Children | 5.93 | 4.53 to 7.32 | 0.54 | 0.91 |
| Adult | 15.08 | 11.49 to 18.67 | 4.05 | 0.04 |
| Therapy | ||||
| Bismuth | 11.55 | 0.09 to 23.01 | 13.61 | 0.0002 |
| PPI | 9.14 | 3.71 to 14.58 | 51.64 | <0.0001 |
| Degree of anaemia | ||||
| Moderate anaemia | 5.96 | 4.51 to 7.40 | 0.51 | 0.77 |
| Marked anaemia | 13.19 | 7.92 to 18.46 | 17.98 | 0.0004 |
| Time period | ||||
| 4 weeks | 2.24 | −2.37 to 6.85 | 7.05 | 0.03 |
| 8 weeks | 9.99 | 5.25 to 14.73 | 69.48 | <0.0001 |
*
The p value is test for heterogeneity of subgroup.
PPI, proton pump inhibitor; WMD, weighted mean difference.