Table 1.

Bioactive compounds that have been reduced in modern food crops

Crop	Latin name	Chemical class	Examples	Targets	Toxicity	References
Cassava	Manihot esculenta	Cyanogenic glycosides	Linamarin, lotaustralin	Cancer	Block cellular respiration	[14]
Celery	Apium graveolens	Furanocoumarins	Psoralen, xanthotoxin, bergapten	Anticoagulant	Photosensitivity	[15,16]
Broccoli	Brassica napa	Glucosinolates	Sulforaphane	Cancer	Goitrogenic	[17,18]
Potato	Solanum tuberosum	Glycoalkaloids	α-Chaconine, α-solanine	Cancer	Neurotoxin	[19,29]
Tomato	L esculentum	Glycoalkaloids	Tomatine	Cancer	Neurotoxin	[26-29]
Common bean	P vulgaris	Glycoproteins	Lectins	Cancer, HIV	Agglutination	[30,31]
Soybean	G max	Isoflavones	Genistein, daidzein	Breast cancer	Estrogenic effects	[20,21]
Cotton	Gossypium spp	Phenolic sesquiterpenes	Gossypol	Cancer, male contraceptive	Infertility	[22,23]
Lettuce	Lactuca sativa	Sesquiterpene lactones	Lactucin, deoxylactucin, lactucopicrin	Inflammation, malaria	Allergenic	[24,25]