Table 1.
Asphyxial Cardiac Arrest Physiological Parameters
| Group | Variable | Before ACA | After ACA | 4hrs after ACA | 24hrs after ACA |
|---|---|---|---|---|---|
| ACA | Body wt (g) | 322.5 ± 2.9 | – | – | – |
| (n = 6) | pH | 7.452 ± 0.018 | 7.309 ± 0.023* | 7.436 ± 0.021 | 7.406 ± 0.00412 |
| PCO2 (mm Hg) | 39.0 ± 1.4 | 40.1 ± 2.7 | 32.9 ± 0.99 | 37.9 ± 2.7 | |
| PO2 (mm Hg) | 127.9 ± 8.3 | 361 ± 52* | 195 ± 36 | 133.3 ± 8.3 | |
| MABP (mm Hg) | 133.7 ± 3.2 | 114.1 ± 4.7 | 111.8 ± 5.1 | 117.1 ± 7.8 | |
| Blood | |||||
| glucose (mg/dL) | 144 ± 10 | – | – | – | |
| Tat+ACA | Body wt (g) | 334 ± 12 | – | – | – |
| (n = 6) | pH | 7.438 ± 0.012 | 7.321 ± 0.033* | 7.442 ± 0.032 | 7.449 ± 0.019 |
| PCO2 (mm Hg) | 38.3 ± 1.9 | 35.5 ± 1.7 | 38.0 ± 4.8 | 36.7 ± 1.9 | |
| PO2 (mm Hg) | 116 ± 12 | 277 ± 48* | 157 ± 37 | 138 ± 10 | |
| MABP (mm Hg) | 127 ± 10 | 113.8 ± 6.2 | 99 ± 14 | 104.3 ± 5.6 | |
| Blood | |||||
| glucose (mg/dL) | 125 ± 12 | – | – | – | |
| δV1-1 + | Body wt (g) | 335 ± 15 | – | – | – |
| ACA | pH | 7.454 ± 0.016 | 7.343 ± 0.044* | 7.503 ± 0.024 | 7.449 ± 0.015 |
| (n = 6) | PCO2 (mm Hg) | 37.9 ± 1.0 | 38.0 ± 3.4 | 31.9 ± 2.2 | 34.1 ± 1.3 |
| PO2 (mm Hg) | 128.4 ± 8.8 | 261 ± 53* | 175 ± 47 | 134 ± 13 | |
| MABP (mm Hg) | 111.5 ± 4.9 | 100.0 ± 2.8 | 107.0 ± 8.1 | 110.3 ± 6.4 | |
| Blood | |||||
| glucose (mg/dL) | 128 ± 14 | – | – | – |
*
indicates significant difference from baseline (Before ACA). We observed the animal to possess slight acidosis shortly after ACA, but was normalized 4 and 24 hrs after ACA. Partial pressure of oxygen (PO2) for all groups (After ACA) were greater than 150 mmHg, due to 100 % delivery of oxygen and increased ventilator rate (60 breaths/min to 80 breaths/min) during and after resuscitation.