Table 3.
Histopathology Physiological Parameters
| Group | Variable | Before ACA | After ACA |
|---|---|---|---|
| Sham | Body wt (g) | 284.1 ± 2.4 | – |
| (n = 8) | pH | 7.455 ± 0.012 | 7.432 ± 0.018 |
| PCO2 (mm Hg) | 37.30 ± 0.58 | 38.00 ± 0.82 | |
| PO2 (mm Hg) | 164.4 ± 7.5 | 148.6 ± 9.2 | |
| MABP (mm Hg) | 117.4 ± 2.5 | 119.8 ± 3.8 | |
| Blood | |||
| glucose (mg/dL) | 165 ± 10 | – | |
| ACA | Body wt (g) | 320.6 ± 15 | – |
| (n = 3) | pH | 7.446 ± 0.013 | 7.371 ± 0.019* |
| PCO2 (mm Hg) | 38.18 ± 0.90 | 39.79 ± 0.94 | |
| PO2 (mm Hg) | 133.8 ± 7.5 | 334 ± 87* | |
| MABP (mm Hg) | 113.1 ± 7.8 | 106.9 ± 8.8 | |
| Blood | |||
| glucose (mg/dL) | 184 ± 25 | – | |
| Tat+ | Body wt (g) | 302.7 ± 6.9 | – |
| ACA | pH | 7.4676 ± 0.0089 | 7.421 ± 0.018* |
| (n = 11) | PCO2 (mm Hg) | 36.9 ± 0.95 | 36.10 ± 0.74 |
| PO2 (mm Hg) | 148.0 ± 8.6 | 354 ± 41* | |
| MABP (mm Hg) | 121.7 ± 4.6 | 116.7 ± 4.6 | |
| Blood | |||
| glucose (mg/dL) | 175.3 ± 6.1 | – | |
| δV1-1+ | Body wt (g) | 324.6 ± 7.8 | – |
| ACA | pH | 7.4354 ± 0.0095 | 7.404 ± 0.013 |
| (n = 9) | PCO2 (mm Hg) | 38.93 ± 0.93 | 40.0 ± 1.3 |
| PO2 (mm Hg) | 148.4 ± 9.8 | 430 ± 28* | |
| MABP (mm Hg) | 114.6 ± 4.6 | 118.3 ± 5.4 | |
| Blood | |||
| glucose (mg/dL) | 197 ± 12 | – |
*
indicates significant difference from baseline (Before ACA). We observed that some animals possess slight acidosis shortly after ACA. PO2 for all groups (with the exception of sham) were greater than 148 mmHg, due to 100 % delivery of oxygen and increased ventilator rate (60 breaths/min to 80 breaths/min) during and after resuscitation.