Table 3.

Areas of Reduced Gray Matter Volume

Cluster Dimension, Voxels	Voxel T Value	Voxel Z Value	Peak MNI Coordinates x, y, z	Anatomic Localization
		In Patients With CBS vs Healthy Controls (Figure 1)a
5690	7.68	6.37	0, 2, 64	Left cerebrum, superior frontal gyrus, BA 6
	7.42	6.21	−2, −46, 66	Left paracentral lobule, BA 5
	7.37	6.18	0, −14, 62	Left medial frontal gyrus, BA 6
501	7.10	6.01	58, −62, −30	Right cerebrum, fusiform gyrus, BA 37
	5.43	4.87	52, −66, −20	Right fusiform gyrus, BA 19
801	6.55	5.66	28, −2, 68	Right cerebrum, middle frontal gyrus, BA 6
	5.82	5.15	58, −4, 50	Right cerebrum, precentral gyrus, BA 6
799	6.52	5.64	6, 10, 12	Right caudate nucleus
	5.63	5.02	2, −18, 14	Right thalamus
66	6.13	5.37	−26, 18, −44	Left cerebrum, superior temporal gyrus, BA 38
125	6.12	5.37	−68, −20, 14	Left postcentral gyrus, BA 40
	5.12	4.63	−68, −18, 22	Left postcentral gyrus, BA 43
	5.02	4.57	−68, −30, 22	Left inferior parietal lobule, BA 40
683	5.80	5.14	−40, 12, −12	Left insula, BA 13
127	5.59	4.99	−58, 2, 42	Left cerebrum, middle frontal gyrus, BA 6
	5.23	4.72	−50, −2, 54	Left precentral gyrus, BA 6
	4.90	4.47	−52, −12, 54	Left postcentral gyrus, BA 3
538	5.57	4.97	44, −8, 6	Right insula, BA 13
73	5.52	4.94	70, −20, 18	Right postcentral gyrus, BA 43
		Associated With TOLA Composite Standard Score (Figure 2)b
44	4.55	4.08	−38, 10, 60	Left middle frontal gyrus, BA 6
49	4.03	3.69	−6, −2, 12	Left caudate nucleus
	3.98	3.65	−62, −2, 38	Left precentral gyrus, BA 6

Abbreviations: BA, Brodmann area; CBS, corticobasal syndrome; MNI, Montreal Neurological Institute; TOLA, Test of Oral and Limb Apraxia.

^aAreas significant at a threshold of 50 voxels when corrected for multiple comparisons with the family-wise error correction at the .05 level.

^bAreas significant at an uncorrected P < .001 level and a threshold of 20 voxels that survived false discovery rate correction.