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. Author manuscript; available in PMC: 2010 Nov 15.
Published in final edited form as: J Am Chem Soc. 2008 Jan 31;130(8):2416–2417. doi: 10.1021/ja710521m

Table 2.

Nitrone Reaction Scope

graphic file with name nihms248683u2.jpg
entry R1 R2 yielda (%) eeb (%)
1 Ph Ph 70 (5) 93
2 4-Me–C6H4 Ph 71 (6) 90
3 4-Br–C6H4 Ph 68 (7) 84
4 4-MeO-C6H4 Ph 62 (8) 90
5 2-naphthyl Ph 69 (9) 81
6 cyclohexyl Ph 0
7 Ph 4Cl-Ph 80 (10) 93
a

Isolated yields.

b

Enantiomeric excess determined by HPLC Chiracel OD-H or AD-H. Diastereomeric ratio determined by 1H NMR spectroscopy (500 MHz).