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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Radiother Oncol. 2010 Apr 12;95(3):327–331. doi: 10.1016/j.radonc.2010.02.030

Table 4.

Study schema for RTOG 0933 phase II trial of hippocampal avoidance during WBRT (HA-WBRT) for brain metastases.

For Patients with MRI Evidence of Brain Metastasis Within 1 Month of WBRT
R
E
G
I
S
T
E
R1 		Within 2 Weeks Prior to Treatment Radiation Therapy Follow Up 3

  1. Stealth MRI with Fused CT Simulation

  2. NCF Testing

  3. Quality of Life Assessment

  4. Central Review of Hippocampal Contours and HA-WBRT Treatment Plan2

 WBRT with Hippocampal Avoidance using
IMRT
(30 Gy in 10 Fractions)

  1. Stealth MRI

  2. NCF Testing

  3. Quality of Life Assessment
1

Institutions must be credentialed by the RTOG prior to enrolling patients. To receive credentialing, institutions must partake in a pilot training project on hippocampal contouring and treatment-planning for hippocampal avoidance during whole-brain radiotherapy.

2

Prior to treatment, all hippocampal contours and HA-WBRT treatment plans will be centrally reviewed for quality assurance. Refinements will be made as needed, and the treatment plans will be returned to the treating physician within 3 business days of submission.

3

Follow up will occur every 2 months for the first 6 months after treatment, then every three months until death.

Abbreviations: NCF, neurocognitive function. HA-WBRT, hippocampal avoidance during whole-brain radiotherapy. IMRT, intensity-modulated radiotherapy.