Skip to main content
. Author manuscript; available in PMC: 2010 Nov 15.
Published in final edited form as: Chem Commun (Camb). 2010 May 25;46(26):4803–4805. doi: 10.1039/c0cc00607f

Scheme 3.

Scheme 3

Reagents and conditions: (a) (−)-7c, pyridone, ClCH2CH2Cl, μW, 53 °C, 2 h (80%, dr 1 : 1); (b) Pd(PPh3)4, morpholine, THF, 1 h, −5 °C; (c) TsCl, 4-PPy, PhMe, −5 °C, 3.5 h (60%, dr 3.5 : 1); (d) H2, Pd/C, THF, 23 °C, 12 h (62%, 82% ee; following recrystallization: 52%, 89% ee).