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. Author manuscript; available in PMC: 2010 Nov 15.
Published in final edited form as: Free Radic Biol Med. 2007 Jul 10;43(7):1023–1036. doi: 10.1016/j.freeradbiomed.2007.06.027

Fig. 2.

Fig. 2

The transmethylation reaction catalyzed DNA methyltransferases (DNMTs). DNMTs catalyze the transfer of the methyl donor group from S-adenosylmethionine (dashed box) to the 5 position of the pyrimidine ring of cytosines within CpG di-nucleotides in genomic DNA. The reaction results in the production of 5-Me-Cytosine and S-adenosylhomocysteine.