Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The reactions catalyzed by proline hydroxylases (PHD), factor inhibiting HIF (FIH), lysine specific demethylase 1 (LSD1), and Jumonji C domain containing proteins (JmjC). All these reactions require oxygen as a cofactor, therefore their activities during development are expected to be regulated by oxygen gradients
