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Schematic showing reduction of carbon-24 double bonds by Δ24 sterol reductases. In mammalian cells, the final step in cholesterol synthesis is reduction of the C24 bond in desmosterol by DHCR24, a Δ24 sterol reductase. Ergosterol is the final sterol in yeast, with the Erg4 Δ24 sterol reductase catalyzing the reduction of ergosta-5,7,22,24(28)-tetraen-3β-ol.
