TABLE 1.

Activity of TFQ enantiomers against L. donovani SbV^a-sensitive strains by the amastigote-peritoneal exudate macrophage model

Drug (unit of activity)	IC50 (±95% confidence interval) for strainb:				Dose achieving cytotoxicity in KB cells
	HU3	DD8	BHU3	BHU11
TFQ (μM)
Racemate	1.75 ± 1.3	1.52 ± 1.02	2.26 ± 1.4	3.69 ± 0.9	6.6
Positive enantiomer	2.26 ± 1.8	3.28 ± 0.45	0.18 ± 3.3	NDc	7.4
Negative enantiomer	4.04 ± 2.2	2.56 ± 0.56	0.10 ± 0.85	ND	7.0
Sitamaquine (μM)	1.03 ± 1.02	1.86 ± 0.2	1.36 ± 0.56	2.35 ± 0.6	506
SbV (μg/ml)	4.49 ± 1.83	13.79 ± 10.17	>50	>50	>300
Miltefosine (μM)	2.01 ± 0.84	4.85 ± 3.89	1.07 ± 0.2	1.77 ± 0.2	31
Amphotericin B (μM)	0.03 ± 0.01	0.04 ± 0.05	0.02 ± 0.01	0.07 ± 0.2	0.7

^aSbV, pentavalent antimony.

^bResults for HU3 represent an average of four tests, and those for DD8 represent an average of two tests.

^cND, not done.