TABLE 2.

In vivo activities of TFQ, sitamaquine, and SbV^a in L. donovani-BALB/c mouse models

Drug (dose)	In vivo activity (% inhibition [±95% confidence interval]) for strain:			ED50 (mg/kg) for strain DD8b
	HU3	BHU1	BHU3
TFQ (5 mg/kg)c
Racemate	99.32 ± 0.31	99.49 ± 0.66	100	1.47 ± 3.9
Positive enantiomer	99.12 ± 0.45	NDd		1.01 ± 9.7
Negative enantiomer	99.03 ± 0.52	ND		3.5 ± 4.8
Sitamaquine (5 mg/kg)	94.48 ± 0.29	ND	98.7 ± 0.6	2.2 ± 7.2
SbV (15 mg/kg)	70.93 ± 10.7	Inactive at 100 mg/kg	Inactive at 100 mg/kg	60% inhibition

^aSbV, pentavalent antimony.

^bNote that amphotericin B (AmBisome) given intravenously at 1 mg/kg for 3 days gives 93% inhibition.

^cTFQ results represent oral administration for 5 days.

^dND, not done.