TABLE 2.
Drug (dose) | In vivo activity (% inhibition [±95% confidence interval]) for strain: |
ED50 (mg/kg) for strain DD8b | ||
---|---|---|---|---|
HU3 | BHU1 | BHU3 | ||
TFQ (5 mg/kg)c | ||||
Racemate | 99.32 ± 0.31 | 99.49 ± 0.66 | 100 | 1.47 ± 3.9 |
Positive enantiomer | 99.12 ± 0.45 | NDd | 1.01 ± 9.7 | |
Negative enantiomer | 99.03 ± 0.52 | ND | 3.5 ± 4.8 | |
Sitamaquine (5 mg/kg) | 94.48 ± 0.29 | ND | 98.7 ± 0.6 | 2.2 ± 7.2 |
SbV (15 mg/kg) | 70.93 ± 10.7 | Inactive at 100 mg/kg | Inactive at 100 mg/kg | 60% inhibition |
SbV, pentavalent antimony.
Note that amphotericin B (AmBisome) given intravenously at 1 mg/kg for 3 days gives 93% inhibition.
TFQ results represent oral administration for 5 days.
ND, not done.