TABLE 1.
Pharmacokinetic parameters for tomopenem and meropenem after single administrations at different doses and a fixed dose of cilastatin in a mouse infection modela
| Drug and dose (mg/kg) | t1/2 (h) | fCmax (μg/ml) | AUC0-inf (μg·h/ml) |
|---|---|---|---|
| Tomopenem/cilastatin | |||
| 50/40 | 0.24 | 44.1 | 32.4 |
| 100/40 | 0.27 | 92.5 | 73.7 |
| 200/40 | 0.39 | 140 | 134 |
| 400/40 | 0.41 | 230 | 261 |
| 800/40 | 0.43 | 346 | 484 |
| Meropenem/cilastatin | |||
| 50/40 | 0.24 | 42.8 | 27.6 |
| 100/40 | 0.18 | 76.8 | 51.1 |
| 200/40 | 0.30 | 175 | 138 |
| 400/40 | 0.28 | 303 | 280 |
| 800/40 | 0.50 | 456 | 551 |
a
Cilastatin was given at a dosage of 40 mg/kg. All parameters are for free, unbound fractions of the drugs.