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Percentages of time above the MICs of the free, unbound fractions of tomopenem and meropenem required for their in vivo efficacies
| Strain |
f%TMIC of indicated drug for effects indicateda |
|||||
|---|---|---|---|---|---|---|
| Tomopenem |
Meropenem |
|||||
| Static (95% CI) | 1-log kill (95% CI) | 2-log kill (95% CI) | Static (95% CI) | 1-log kill (95% CI) | 2-log kill (95% CI) | |
| P. aeruginosa 12467 | 29 (25-33) | 39 (35-43) | 51 (45-58) | 24 (21-28) | 33 (30-37) | 45 (39-52) |
| MRSA 12372 | 27 (24-29) | 35 (31-37) | 47 (39-52) | ND | ND | ND |
ND, not determined.
