TABLE 1.

Antagonists of B. anthracis spore germination in vitro^a

Antagonist	Acronym	IC50 (mM)
6-Thioguanosine	6-TG	1.00
6-Chloroguanosine	6-CG	0.89
6-Benzylthioinosine	6-BTI	0.05
6-Methylmercaptopurine riboside	6-MMPR	0.32
6-O-Methylguanosine	6-OMG	0.35
2-Aminoadenosine	2-AADE	0.70
Xanthosine	XAN	7.19
6-Methylaminopurine riboside	6-MAPR	0.19
2-Aminopurine riboside	2-APR	0.38
Ribofuranosyl-((9H-purin-6-yl) piperazin-1-yl)ethanone	6-PPER	0.05
6-N-Benzylmethyladenosine	6-BMA	0.12
6-N-Benzylaminopurine	6-BAP	1.55
6-(γ,γ-Dimethylallyl amino)purine riboside	6-DMAA	0.36
6-N-Benzoyladenosine	6-NBA	1.14
6-N-Piperidineadenosine	6-PPA	1.09
6-N-Diethyladenosine	6-DEA	0.31
6-N-Dipropyladenosine	6-DPA	0.76
6-N-((3-Ethylacetyl)cyclohexyl) adenosine	6-ECA	0.70
d-Alanine	d-Ala	0.02

^aSpore suspensions were individually supplemented with various concentration of compounds II to XLVI and then treated with 250 μM inosine and 40 μM l-alanine. Compounds that did not inhibit germination are not shown in this table.