TABLE 2.
Protection of macrophages from B. anthracis-mediated killinga
| Antagonist | Acronym | IC50 (mM) |
|---|---|---|
| 6-Thioguanosine | 6-TG | 0.004 |
| 6-Chloroguanosine | 6-CG | 0.19 |
| 6-Thioinosine | 6-TI | 0.04 |
| Allopurinol riboside | APR | 0.65 |
| 6-Benzylthioinosine | 6-BTI | 1.04 |
| 6-Thioguanine | 6-Tg | 0.002 |
| 6-Chloroguanine | 6-Cg | 0.20 |
| 6-Mercaptopurine | 6-Mp | 0.40 |
| d-Alanine | d-Ala | 0.02 |
a
Macrophage cultures were individually supplemented with various concentrations of compounds II to XLVI and then infected with B. anthracis spores. Compounds that did not protect macrophages from anthrax cytotoxicity are not shown in this table.