TABLE 2.
In vitro susceptibilities for paired isolates tested at ring (>90% before culture) and trophozoite (>90% after culture in the absence of drug) stages
| Drug |
P. falciparum |
P. vivax |
||||||
|---|---|---|---|---|---|---|---|---|
| n | Median IC50 (range) (nM) |
P | n | Median IC50 (range) (nM) |
P | |||
| Rings | Trophozoites | Rings | Trophozoites | |||||
| Pyronaridine | 11 | 1.6 (0.6-8.9) | 8.0 (1.2-21.7) | 0.015 | 8 | 2.5 (1.4-15.6) | 4.7 (1.4-18.7) | 0.085 |
| Chloroquine | 8 | 34.6 (11.9-55.0) | 60.6 (19.6-157.8) | 0.125 | 8 | 49.2 (18.3-171.8) | 2427 (384-4457) | 0.04 |
| Amodiaquine | 8 | 8.1 (2.6-16.2) | 12.6 (0.4-22.4) | 0.805 | 8 | 16.5 (6.7-37.9) | 25.2 (12.5-59.9) | 0.18 |
| Mefloquine | 11 | 4.9 (1.6-14.8) | 8.5 (2.4-34.1) | 0.04 | 8 | 7.9 (1.3-24.6) | 12.4 (1.9-25.0) | 0.615 |
| Piperaquine | 10 | 11.8 (2.7-30.4) | 77.2 (13.6-1195) | 0.025 | 8 | 14.0 (8.4-42.0) | 21.7 (10.5-62.0) | 0.085 |