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. 2010 Sep 20;54(12):5214–5221. doi: 10.1128/AAC.01054-10

TABLE 1.

Bacteriostatic and bactericidal activities of fluoroquinolones

Compound	C-7 ring structure	MIC (μg/ml)	LD₉₉^c (μg/ml)	LD₉₉/MIC
PD161144^a	N-Ethyl piperazinyl	0.1	0.14	1.4
UING4-257^b	N-Ethyl piperazinyl	0.75	1.5	2.0
UIHS-IIa-93^a	N-Methyl piperazinyl	0.062	2.0	3.2
Levofloxacin^b	N-Methyl piperazinyl	0.2	0.8	4.0
PD135042^a	H-Piperazinyl	0.031	0.04	1.3
UING4-255^b	H-Piperazinyl	1.0	1.2	1.2
PD161148^a	C-Ethyl piperazinyl	0.16	0.8	5.0
UIKRM-1-025^b	C-Ethyl piperazinyl	0.25	0.5	2.0
Gatifloxacin^a	C-Methyl piperazinyl	0.04	0.2	5.0
UIKRM-1-029^b	C-Methyl piperazinyl	0.31	0.74	2.4
Moxifloxacin^a	Diazabicyclo	0.125	0.5	4.0
UIKRM-1-033^b	Diazabicyclo	0.125	0.25	2.0
Pazufloxacin^b	Aminocyclopropyl	0.02	0.08	4.0
Marbofloxacin^b	N-Methyl piperazinyl	0.02	0.06	3.0
Rufloxacin^b	N-Methyl piperazinyl	1.0	7.0	7.0

^a

Open-ring structure.

^b

Fused-ring structure.

^c

LD₉₉, 99% lethal dose.