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. 2010 Sep 20;54(12):5028–5041. doi: 10.1128/AAC.00327-10

FIG. 6.

FIG. 6.

Ultrastructural alterations detected by transmission electron microscopy in L. major promastigotes treated with compound 13b for 1, 2, or 10 h. (A to D) Destruction of lysosome-like vacuoles and mitochondrial swelling in compound 13b-treated promastigotes after 1 and 2 h of incubation. (E and F) Karyolysis and destruction of intracellular organelles during the late phase of cell death in L. major promastigotes treated with cysteine cathepsin inhibitor for 10 h. Chromatin condensation is indicated by arrowheads. dM, dilated mitochondrion; F, flagellum; kDNA, kinetoplast DNA; L, lysosome-like vacuoles; MVB, multivesicular bodies; N, nucleus.