TABLE 3.
MICs for S. marcescens wild strains and transconjugants
| Antimicrobial agentb | MIC (μg/ml) rangea |
||
|---|---|---|---|
| Wild strain | Transconjugant | E. coli J53 | |
| Piperacillin | >256 | 256->256 | 1 |
| Cefoxitin | >256 | 4-8 | 4 |
| Cefotaxime | >256 | 32-128 | ≤0.12 |
| Ceftazidime | 128-256 | 2-4 | 0.25 |
| Aztreonam | 64-128 | 8-16 | ≤0.12 |
| Imipenem | 4-8 | 0.12-0.25 | 0.12 |
| Imipenem + clavulanic acid | 4-8 | 0.06-0.12 | 0.12 |
| Imipenem + boronic acid | 0.5-2 | ND | ND |
| Imipenem + PAβN | 4-8 | ND | ND |
| Imipenem + cloxacillin | 0.094-1 | ND | ND |
| Meropenem | 16-32 | 0.015-0.03 | 0.03 |
| Meropenem + clavulanic acid | 16-32 | 0.015 | 0.015 |
| Meropenem + boronic acid | 1-4 | ND | ND |
| Meropenem + PAβN | 8-32 | ND | ND |
| Meropenem + cloxacillin | 0.008-0.5 | ND | ND |
| Gentamicin | >256 | 32 | 0.5 |
| Ciprofloxacin | 8-32 | 0.12 | 0.12 |
a
ND, not detected.
b
Clavulanic acid, boronic acid, cloxacillin, and PAβN were added at fixed concentrations of 4 μg/ml, 300 μg/ml, 250 μg/ml, and 20 μg/ml, respectively.