FIG. 4.

Complement C3 deposition (A) and concentration of anticapsular antibodies required for 50% opsonophagocytic killing (B) of pneumococcal clinical isolates and reference strains was associated with serotype-specific mortality of IPD in patients aged 5 years or older (17). The number of strains in the overlapping symbols is shown inside the brackets. Correlation of IPD severity with the antibody concentration required for opsonophagocytic killing was significant when serotype 19F reference strain was excluded. **, P < 0.01 (Pearson correlation).