FIG. 6.
Overexpression of PyMIF reduces peak parasitemia during nonlethal P. yoelii 17X malaria. (A and B) Groups of BALB/cByJ (A) and C57BL/6 (B) mice (10 animals/group) were infected i.p. with 1 × 105 Py17X-GFP (○) or Py17X-MIF(+) (▴) parasites and monitored for parasitemia. The mean percent parasitemia (± standard deviation [SD]) in each group is plotted versus days postinfection. (C) The mean percent parasitemias (±SD) on day 8 and day 10 of infection were comparable for Py17X-GFP- and Py17X-MIF(+)-infected mice. (D) Mean peak parasitemia (±SD) was significantly reduced (P < 0.05 by an unpaired Student's t test) in Py17X-MIF(+)-infected mice relative to Py17X-GFP-infected controls irrespective of the mouse genetic background.