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. 2010 Sep 20;78(12):5043–5053. doi: 10.1128/IAI.00604-10

FIG. 6.

FIG. 6.

MEK1 activation attenuates LT effects. While the injection of LT resulted in pericardial edema, enlarged heart chambers, and reduced or absent blood circulation in wild-type and tg(hsp70:MEK1) embryos (B and C), most tg(hsp70:MEK1DD) embryos were rescued from toxin effects (D). Black arrows mark differences in pericardial edema between the lines and treatment conditions used. (E to H) Vascular permeability following LT injection was assessed by testing for the extravasation of fluorescent microspheres in tg(hsp70:MEK1DD), tg(hsp70:MEK1), and wild-type embryos. While bead leakage from the dorsal aorta was detected in wild-type and tg(hsp70:MEK1) embryos (F and G), no bead leakage from tg(hsp70:MEK1DD) transgenic animals was detected (H). An LT dose of 150 fmol LF and 100 fmol PA was used in these experiments.