TABLE 1.

The δH68A mutation does not change the Zn²⁺ sensitivity of α4β3δ receptors expressed in oocytes

Zn²⁺ sensitivity of agonist (e.g., 300 nM GABA) evoked currents was evaluated at 0.1, 1, and 10 μM Zn²⁺ and data are percent current block with standard deviations. Statistical analysis, with P values calculated using the Student's t test, shows that there is no significant difference in Zn²⁺ block at all three Zn²⁺ concentrations tested.

	[Zn2+]
	0.1 μM	1 μM	10 μM
α4β3δ (n = 6) % block	0.8 ± 1.4	26.3 ± 2.1	88.8 ± 11.8
α4β3δH68A (n = 7) % block	1.4 ± 1.9	27.1 ± 6.7	81.4 ± 10.7
P value, δ versus δH68A	0.54	0.95	0.26