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The modification rate by Ag+ on BK current is not altered in the presence of channel blocker. A, time course of BK modification by 520 nM Ag+ in the presence of 600 μM TBA. The patch was first perfused in 600 μM TBA for 10 s and then switched to a solution containing both TBA and 520 nM Ag+ for modification. B, the histogram of mean modification time constants by 520 nM Ag+ with 0 (3.5 ± 0.8 s, n = 6) or 600 μM (3.01 ± 1.05 s, n = 6) TBA.
