TABLE 1.
Summary of test compounds
Compounds 1–8 show positive responses and are presented in order of high to low potency. Compounds 9 and 10 had negative responses and contain structures similar to that of pamoic acid.
| Compound Number | Compound Name | Structure | EC50 |
|---|---|---|---|
| 1 | Pamoic acid |
|
79 nM |
| 2 | Pyrantel pamoate |
|
83 nM |
| 3 | Oxantel pamoate |
|
91 nM |
| 4 | Zaprinast |
|
1.0 μM |
| 5 | NPPB |
|
4.4 μM |
| 6 | DHNA |
|
45 μM |
| 7 | 3-Hydroxy-2-naphthoic acid |
|
86 μM |
| 8 | Kynurenic acid |
|
217 μM |
| 9 | Salicylic acid |
|
No response |
| 10 | Acetylsalicylic acid (aspirin) |
|
No response |