Figure 3.

Comparative expression analysis of miRNAs (miR-21, miR-221 and miR-146a) in the plasma of 32 PC patients analyzed individually compared to plasma samples obtained from 10 normal subjects by using qRT-PCR. The line drawn at 1.0 represents average of normal subjects (n=10). The results showed a significant increase in the expression of miR-21 and miR-221 (oncogene) over the cutoff of 1.0 by almost all PC patients. In contrast, a significant down-regulation of miR-146a (tumor suppressor gene) was observed in PC patients compared to normal subjects.