Table 2.
Statistical and clustering analysis of miRNA data between the three groups
Group 1 | Group 2 | Group 3 | |||
---|---|---|---|---|---|
MIAPaCa-2 | MIAPaCa-GR | MIAPaCa-GTR | |||
No. | Reporter Name | p-value | Mean | Mean | Mean |
156 | hsa-miR-1308 | 4.32E-10 | 173 | 745 | 569 |
852 | hsa-miR-886-5p | 2.82E-09 | 587 | 132 | 90 |
293 | hsa-miR-1975 | 1.69E-08 | 1,715 | 5,918 | 4,848 |
247 | hsa-miR-185 | 6.34E-08 | 291 | 673 | 674 |
273 | hsa-miR-1915 | 8.97E-08 | 173 | 651 | 527 |
868 | hsa-miR-92a | 9.62E-08 | 3,823 | 1,596 | 1,754 |
100 | hsa-miR-126 | 1.10E-07 | 534 | 971 | 902 |
157 | hsa-miR-130a | 1.12E-07 | 351 | 802 | 634 |
432 | hsa-miR-320a | 1.12E-07 | 3,847 | 2,072 | 2,084 |
119 | hsa-miR-1275 | 1.16E-07 | 666 | 188 | 291 |
817 | hsa-miR-7 | 1.38E-07 | 1,610 | 565 | 423 |
824 | hsa-miR-720 | 1.73E-07 | 1,134 | 364 | 370 |
433 | hsa-miR-320b | 1.95E-07 | 4,053 | 2,110 | 2,051 |
434 | hsa-miR-320c | 2.27E-07 | 4,185 | 2,193 | 2,141 |
435 | hsa-miR-320d | 4.31E-07 | 3,040 | 1,599 | 1,624 |
126 | hsa-miR-1280 | 5.48E-07 | 1,175 | 478 | 668 |
355 | hsa-miR-22 | 5.80E-07 | 236 | 495 | 482 |
223 | hsa-miR-15a | 6.85E-07 | 759 | 1,399 | 1,806 |
417 | hsa-miR-30a | 7.29E-07 | 912 | 2,288 | 2,541 |
780 | hsa-miR-638 | 9.17E-07 | 489 | 853 | 881 |
473 | hsa-miR-361-5p | 1.01E-06 | 807 | 1,524 | 1,608 |
426 | hsa-miR-30e | 1.42E-06 | 420 | 896 | 1,169 |
424 | hsa-miR-30d | 1.76E-06 | 552 | 1,210 | 1,306 |
80 | hsa-miR-1246 | 1.86E-06 | 3,605 | 8,071 | 7,683 |
871 | hsa-miR-92b | 2.02E-06 | 1,397 | 637 | 720 |
327 | hsa-miR-20b | 2.88E-06 | 2,375 | 1,239 | 1,247 |
521 | hsa-miR-424 | 3.83E-06 | 250 | 540 | 667 |
385 | hsa-miR-27a | 4.38E-06 | 1,538 | 2,819 | 3,093 |
292 | hsa-miR-1974 | 6.60E-06 | 15,945 | 9,498 | 8,684 |
297 | hsa-miR-1979 | 6.90E-06 | 6,301 | 5,431 | 3,752 |
419 | hsa-miR-30b | 8.50E-06 | 453 | 854 | 903 |
213 | hsa-miR-151-5p | 1.00E-05 | 883 | 1,432 | 1,313 |
230 | hsa-miR-17 | 1.04E-05 | 3,486 | 2,408 | 1,865 |
29 | hsa-miR-106a | 1.11E-05 | 3,465 | 2,424 | 1,880 |
360 | hsa-miR-221 | 1.59E-05 | 5,421 | 7,191 | 8,200 |
325 | hsa-miR-20a | 2.04E-05 | 3,911 | 2,789 | 2,245 |
34 | hsa-miR-10a | 2.32E-05 | 480 | 279 | 200 |
227 | hsa-miR-16 | 2.43E-05 | 8,590 | 13,443 | 11,781 |
380 | hsa-miR-26a | 3.02E-05 | 2,496 | 3,740 | 3,922 |
10 | hsa-let-7e | 4.98E-05 | 2,287 | 1,338 | 2,377 |
329 | hsa-miR-21 | 6.57E-05 | 16,363 | 18,437 | 24,832 |
387 | hsa-miR-27b | 8.97E-05 | 565 | 950 | 1,069 |
523 | hsa-miR-425 | 1.06E-04 | 335 | 674 | 613 |
890 | hsa-miR-98 | 1.21E-04 | 492 | 436 | 635 |
283 | hsa-miR-195 | 1.85E-04 | 221 | 416 | 408 |
399 | hsa-miR-29b | 2.39E-04 | 373 | 569 | 662 |
478 | hsa-miR-365 | 2.91E-04 | 466 | 164 | 147 |
31 | hsa-miR-106b | 7.19E-04 | 1,724 | 2,563 | 2,211 |
6 | hsa-let-7c | 8.52E-04 | 4,155 | 3,708 | 4,967 |
893 | hsa-miR-99b | 1.14E-03 | 730 | 677 | 550 |
33 | hsa-miR-107 | 1.23E-03 | 1,931 | 2,816 | 2,544 |
492 | hsa-miR-374b | 1.27E-03 | 586 | 645 | 841 |
4 | hsa-let-7b | 1.83E-03 | 2,002 | 2,375 | 2,684 |
24 | hsa-miR-103 | 1.90E-03 | 2,130 | 3,091 | 2,599 |
397 | hsa-miR-29a | 2.11E-03 | 7,701 | 11,078 | 9,797 |
718 | hsa-miR-584 | 2.21E-03 | 895 | 655 | 617 |
242 | hsa-miR-1826 | 2.28E-03 | 19,150 | 20,015 | 15,659 |
17 | hsa-let-7i | 2.72E-03 | 9,341 | 12,161 | 11,956 |
418 | hsa-miR-30a* | 2.89E-03 | 578 | 739 | 853 |
244 | hsa-miR-183 | 4.36E-03 | 573 | 574 | 456 |
225 | hsa-miR-15b | 4.40E-03 | 4,731 | 3,494 | 3,966 |
125 | hsa-miR-128 | 4.99E-03 | 558 | 671 | 748 |
239 | hsa-miR-182 | 5.19E-03 | 1,049 | 1,367 | 1,142 |
264 | hsa-miR-191 | 7.20E-03 | 1,812 | 2,120 | 2,091 |
421 | hsa-miR-30c | 7.23E-03 | 1,699 | 2,165 | 2,428 |
873 | hsa-miR-93 | 7.92E-03 | 2,239 | 2,187 | 1,772 |
402 | hsa-miR-29c | 7.98E-03 | 544 | 661 | 776 |
362 | hsa-miR-222 | 8.28E-03 | 5,701 | 5,760 | 6,566 |
249 | hsa-miR-186 | 8.85E-03 | 429 | 493 | 382 |
Following transcripts are statistically significant but have low signals (signal < 500) | |||||
232 | hsa-miR-181a | 6.03E-09 | 66 | 289 | 177 |
204 | hsa-miR-148a | 1.92E-08 | 33 | 215 | 211 |
741 | hsa-miR-605 | 5.62E-08 | 8 | 219 | 34 |
255 | hsa-miR-18a | 2.63E-07 | 441 | 281 | 189 |
161 | hsa-miR-132 | 1.27E-06 | 49 | 90 | 100 |
464 | hsa-miR-345 | 1.78E-06 | 51 | 137 | 150 |
36 | hsa-miR-10b | 2.03E-06 | 264 | 106 | 81 |
127 | hsa-miR-1281 | 2.14E-06 | 20 | 86 | 77 |
405 | hsa-miR-301a | 2.50E-06 | 100 | 209 | 95 |
475 | hsa-miR-362-5p | 2.92E-06 | 103 | 185 | 172 |
770 | hsa-miR-629 | 3.58E-06 | 58 | 109 | 107 |
199 | hsa-miR-146b-5p | 4.32E-06 | 28 | 76 | 73 |
285 | hsa-miR-196a | 4.57E-06 | 42 | 20 | 9 |
275 | hsa-miR-192 | 4.94E-06 | 122 | 319 | 232 |
214 | hsa-miR-152 | 5.89E-06 | 177 | 327 | 284 |
647 | hsa-miR-532-5p | 6.80E-06 | 186 | 389 | 381 |
803 | hsa-miR-660 | 9.13E-06 | 153 | 310 | 330 |
22 | hsa-miR-101 | 1.02E-05 | 125 | 272 | 272 |
110 | hsa-miR-1268 | 1.12E-05 | 191 | 89 | 86 |
159 | hsa-miR-130b | 1.29E-05 | 203 | 368 | 283 |
195 | hsa-miR-1469 | 1.80E-05 | 88 | 197 | 183 |
707 | hsa-miR-575 | 1.82E-05 | 26 | 64 | 51 |
137 | hsa-miR-1290 | 1.85E-05 | 30 | 103 | 95 |
737 | hsa-miR-601 | 1.92E-05 | 47 | 29 | 21 |
851 | hsa-miR-886-3p | 2.01E-05 | 231 | 99 | 77 |
257 | hsa-miR-18b | 2.08E-05 | 171 | 126 | 87 |
281 | hsa-miR-194 | 2.32E-05 | 105 | 225 | 216 |
176 | hsa-miR-137 | 2.54E-05 | 93 | 43 | 43 |
814 | hsa-miR-671-5p | 5.15E-05 | 186 | 104 | 88 |
439 | hsa-miR-324-5p | 5.50E-05 | 72 | 139 | 135 |
356 | hsa-miR-22* | 5.93E-05 | 90 | 183 | 213 |
117 | hsa-miR-1274a | 6.22E-05 | 91 | 62 | 61 |
291 | hsa-miR-1973 | 6.79E-05 | 33 | 102 | 78 |
196 | hsa-miR-146a | 8.06E-05 | 11 | 35 | 11 |
9 | hsa-let-7d* | 8.26E-05 | 312 | 167 | 180 |
576 | hsa-miR-500* | 8.41E-05 | 87 | 126 | 130 |
518 | hsa-miR-422a | 9.15E-05 | 106 | 48 | 71 |
474 | hsa-miR-362-3p | 9.80E-05 | 32 | 62 | 68 |
764 | hsa-miR-625 | 1.19E-04 | 14 | 24 | 35 |
546 | hsa-miR-455-3p | 1.45E-04 | 90 | 189 | 140 |
472 | hsa-miR-361-3p | 1.52E-04 | 26 | 47 | 47 |
829 | hsa-miR-760 | 1.53E-04 | 107 | 67 | 41 |
26 | hsa-miR-103-as | 1.61E-04 | 44 | 73 | 76 |
847 | hsa-miR-877 | 1.86E-04 | 109 | 51 | 50 |
554 | hsa-miR-486-5p | 1.89E-04 | 235 | 114 | 177 |
771 | hsa-miR-629* | 3.80E-04 | 24 | 52 | 47 |
553 | hsa-miR-486-3p | 4.53E-04 | 97 | 57 | 109 |
831 | hsa-miR-762 | 4.92E-04 | 180 | 271 | 339 |
149 | hsa-miR-1301 | 5.00E-04 | 60 | 114 | 81 |
778 | hsa-miR-636 | 5.15E-04 | 20 | 17 | 35 |
537 | hsa-miR-450a | 5.94E-04 | 44 | 63 | 99 |
236 | hsa-miR-181c | 6.10E-04 | 24 | 55 | 37 |
882 | hsa-miR-940 | 6.14E-04 | 105 | 112 | 181 |
879 | hsa-miR-937 | 6.24E-04 | 19 | 30 | 34 |
289 | hsa-miR-197 | 6.38E-04 | 149 | 92 | 100 |
254 | hsa-miR-188-5p | 7.43E-04 | 69 | 34 | 35 |
182 | hsa-miR-140-3p | 7.62E-04 | 124 | 197 | 171 |
834 | hsa-miR-766 | 7.77E-04 | 20 | 45 | 51 |
83 | hsa-miR-1249 | 7.99E-04 | 117 | 44 | 131 |
878 | hsa-miR-936 | 8.40E-04 | 36 | 13 | 20 |
724 | hsa-miR-589* | 8.64E-04 | 9 | 27 | 23 |
511 | hsa-miR-409-3p | 1.03E-03 | 13 | 37 | 25 |
470 | hsa-miR-34c-3p | 1.03E-03 | 16 | 42 | 35 |
646 | hsa-miR-532-3p | 1.12E-03 | 139 | 183 | 256 |
583 | hsa-miR-505 | 1.17E-03 | 53 | 71 | 88 |
706 | hsa-miR-574-5p | 1.28E-03 | 354 | 236 | 211 |
575 | hsa-miR-500 | 1.30E-03 | 75 | 94 | 108 |
806 | hsa-miR-663 | 1.40E-03 | 98 | 139 | 209 |
183 | hsa-miR-140-5p | 1.57E-03 | 38 | 52 | 60 |
160 | hsa-miR-130b* | 1.76E-03 | 85 | 58 | 69 |
677 | hsa-miR-548q | 2.00E-03 | 27 | 43 | 34 |
73 | hsa-miR-1237 | 2.53E-03 | 61 | 37 | 90 |
888 | hsa-miR-96 | 2.82E-03 | 66 | 90 | 97 |
209 | hsa-miR-149* | 2.91E-03 | 99 | 139 | 166 |
794 | hsa-miR-652 | 3.29E-03 | 46 | 64 | 52 |
490 | hsa-miR-374a | 3.40E-03 | 449 | 291 | 349 |
88 | hsa-miR-1254 | 3.52E-03 | 66 | 14 | 15 |
877 | hsa-miR-935 | 3.76E-03 | 31 | 17 | 27 |
172 | hsa-miR-135b | 4.12E-03 | 87 | 47 | 54 |
881 | hsa-miR-939 | 4.15E-03 | 43 | 24 | 26 |
567 | hsa-miR-494 | 4.67E-03 | 20 | 38 | 51 |
579 | hsa-miR-502-3p | 4.91E-03 | 79 | 98 | 119 |
48 | hsa-miR-1201 | 4.92E-03 | 32 | 30 | 17 |
74 | hsa-miR-1238 | 5.15E-03 | 40 | 28 | 68 |
446 | hsa-miR-331-3p | 5.30E-03 | 81 | 136 | 135 |
822 | hsa-miR-718 | 5.52E-03 | 29 | 36 | 59 |
449 | hsa-miR-335* | 5.55E-03 | 9 | 32 | 14 |
238 | hsa-miR-181d | 5.97E-03 | 78 | 90 | 60 |
651 | hsa-miR-542-3p | 6.70E-03 | 31 | 50 | 71 |
208 | hsa-miR-149 | 6.86E-03 | 44 | 55 | 89 |
206 | hsa-miR-148b | 7.01E-03 | 294 | 377 | 380 |
270 | hsa-miR-1913 | 7.25E-03 | 65 | 44 | 130 |
524 | hsa-miR-425* | 7.49E-03 | 19 | 31 | 35 |
496 | hsa-miR-376a* | 7.57E-03 | 4 | 22 | 0 |
887 | hsa-miR-95 | 7.61E-03 | 12 | 17 | 30 |
245 | hsa-miR-183* | 7.69E-03 | 55 | 47 | 34 |
699 | hsa-miR-568 | 7.90E-03 | 19 | 21 | 10 |
16 | hsa-let-7g* | 7.92E-03 | 26 | 13 | 20 |
372 | hsa-miR-23a* | 9.40E-03 | 38 | 22 | 23 |
377 | hsa-miR-24-2* | 9.41E-03 | 51 | 71 | 75 |