In vivo MRSA photoinactivation with Py3MeO-TBPo. (A) Dose response of bacterial luminescence from burns infected with luminescent MRSA and treated with 100 μM of porphycene 3 and 652 nm light (PDT), with 100 μM of Py3MeO-TBPo only (DC), with light (LC) only, and without treatment (NTC). (B) Light-dose response curves of the normalized bioluminescence for mice treated with photodynamic therapy (red), mice treated only with Py3MeO-TBPo (brown), mice treated only with light (yellow), and without treatment (green). Every point is an average of five independent mice. *, P < 0.001.