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. Author manuscript; available in PMC: 2010 Nov 15.
Published in final edited form as: J Cell Physiol. 2009 May;219(2):438–448. doi: 10.1002/jcp.21687

Fig. 9.

Fig. 9

Control of the HiNF-P/p220NPAT pathway by p57KIP2. Histone H4 gene transcription is controlled by the HiNF-P/p220NPAT complex that is activated in parallel to the E2F/pRB pathway that controls transcription of genes involved in nucleotide metabolism and DNA synthesis. Both pathways are responsive to growth factor dependent induction of CDK2/cyclin E at the R-point, and thus sensitive to the levels of CDK inhibitors. The findings in this study suggest that while p57KIP2 is not a strong CDK inhibitor, it can effectively inhibit CDK phosphorylation of p220NPAT through direct protein/protein interactions. It is possible that p57KIP2 can be recruited to histone gene promoters through interaction with the HiNF-P/p220NPAT complex.