Table III.
Multivariate analysis of estrogen-related SNPs associated with lung cancer survival
| NCI-MD case–case study |
NCI-MD case–control study |
Norwegian case-only study |
|||||||
| SNP | n (%) | HR (95% CI)ab | P-value | n (%) | HR (95% CI)ac | P-value | n (%) | HR (95% CI)de | P-value |
| Comt-01 | |||||||||
| G/G | 80 (35) | 1.00 (reference) | 59 (28) | 1.00 (reference) | 86 (35) | 1.00 (reference) | |||
| G/A | 100 (44) | 0.97 (0.60–1.58) | 0.911 | 103 (48) | 0.65 (0.32–1.36) | 0.256 | 114 (46) | 0.90 (0.56–1.46) | 0.682 |
| A/A | 47 (21) | 1.33 (0.77–2.29) | 0.306 | 51 (24) | 0.99 (0.55–1.80) | 0.979 | 47 (19) | 1.50 (0.87–2.60) | 0.146 |
| Cyp17a1-01 | |||||||||
| T/T | 84 (35) | 1.00 (reference) | 80 (37) | 1.00 (reference) | 93 (37) | 1.00 (reference) | |||
| T/C | 114 (48) | 1.57 (0.99–2.49) | 0.053 | 108 (50) | 0.87 (0.51–1.48) | 0.610 | 123 (49) | 0.63 (0.32–1.24) | 0.183 |
| C/C | 39 (16) | 1.30 (0.71–2.38) | 0.397 | 27 (13) | 1.25 (0.61–2.52) | 0.543 | 33 (13) | 0.78 (0.50–1.21) | 0.265 |
| Cyp17a1-05 | |||||||||
| C/C | 29 (34) | 1.00 (reference) | 81 (37) | 1.00 (reference) | 92 (37) | 1.00 (reference) | |||
| C/T | 42 (49) | 1.11 (0.48–2.56) | 0.800 | 106 (48) | 0.93 (0.46–1.88) | 0.848 | 119 (48) | 1.27 (0.69–2.35) | 0.449 |
| T/T | 15 (17) | 0.69 (0.26–1.81) | 0.449 | 33 (15) | 0.90 (0.46–1.78) | 0.763 | 38 (15) | 1.62 (0.85–3.09) | 0.145 |
| Cyp19a1-01 | |||||||||
| A/A | 69 (29) | 1.00 (reference) | 77 (36) | 1.00 (reference) | 67 (27) | 1.00 (reference) | |||
| A/G | 98 (41) | 0.80 (0.36–1.77) | 0.582 | 91 (43) | 0.93 (0.43–2.03) | 0.864 | 121 (50) | 1.43 (0.79–2.60) | |
| G/G | 70 (30) | 1.08 (0.44–2.62) | 0.866 | 43 (20) | 1.51 (0.86–2.67) | 0.152 | 56 (23) | 1.25 (0.72–2.20) | |
| Cyp19a1-06 | |||||||||
| T/T | 64 (27) | 1.00 (reference) | 74 (35) | 1.00 (reference) | 70 (28) | 1.00 (reference) | |||
| T/G | 118 (50) | 0.97 (0.60–1.55) | 0.888 | 96 (45) | 0.98 (0.46–2.08) | 0.964 | 123 (50) | 0.86 (0.55–1.35) | 0.502 |
| G/G | 56 (24) | 0.84 (0.48–1.50) | 0.564 | 43 (20) | 1.57 (0.79–3.12) | 0.194 | 55 (22) | 0.53 (0.28–1.00) | 0.053 |
| Cyp19a1-08 | |||||||||
| T/T | 132 (55) | 1.00 (reference) | 123 (56) | 1.00 (reference) | 131 (53) | 1.00 (reference) | |||
| T/G | 96 (40) | 0.32 (0.15–0.72) | 0.004 | 78 (36) | 0.72 (0.34–1.52) | 0.388 | 100 (40) | 0.69 (0.40–1.10) | 0.130 |
| T/T | 12 (5) | 0.41 (0.19–0.88) | 0.034 | 18 (8) | 0.62 (0.30–1.26) | 0.185 | 18 (7) | 0.46 (0.23–0.88) | 0.020 |
| Cyp19a1-09 | |||||||||
| C/C | 70 (30) | 1.00 (reference) | 79 (36) | 1.00 (reference) | 70 (28) | 1.00 (reference) | |||
| C/T | 98 (42) | 0.75 (0.35–1.61) | 0.462 | 96 (44) | 0.87 (0.40–1.89) | 0.724 | 123 (50) | 0.84 (0.54–1.33) | 0.460 |
| T/T | 66 (28) | 0.71 (0.26–1.94) | 0.506 | 45 (20) | 1.50 (0.88–2.58) | 0.140 | 55 (22) | 0.53 (0.28–1.00) | 0.052 |
| Cyp19a1-14 | |||||||||
| C/C | 75 (31) | 1.00 (reference) | 90 (41) | 1.00 (reference) | 66 (27) | 1.00 (reference) | |||
| C/T | 114 (48) | 0.98 (0.58–1.68) | 0.951 | 89 (41) | 1.19 (0.56–2.53) | 0.656 | 122 (49) | 0.81 (0.51–1.29) | 0.367 |
| T/T | 50 (21) | 1.14 (0.65–1.98) | 0.652 | 40 (18) | 1.58 (0.78–3.20) | 0.206 | 59 (24) | 0.62 (0.34–1.13) | 0.115 |
| Esr1-01 | |||||||||
| T/T | 60 (30) | 1.00 (reference) | 56 (26) | 1.00 (reference) | 73 (29) | 1.00 (reference) | |||
| T/C | 90 (44) | 0.95 (0.56–1.61) | 0.856 | 118 (54) | 1.16 (0.50–2.65) | 0.732 | 128 (51) | 0.97 (0.60–1.57) | 0.910 |
| C/C | 53 (26) | 1.01 (0.57–1.81) | 0.965 | 45 (21) | 2.22 (1.11–4.45) | 0.024 | 49 (20) | 1.41 (0.80–2.49) | 0.232 |
| Esr1-07 | |||||||||
| G/G | 53 (25) | 1.00 (reference) | 142 (65) | 1.00 (reference) | 159 (64) | 1.00 (reference) | |||
| G/A | 126 (59) | 1.69 (1.07–2.67) | 0.050 | 73 (33) | 1.08 (0.26–4.48) | 0.917 | 82 (33) | 1.54 (1.01–2.36) | 0.040 |
| A/A | 34 (16) | 2.59 (1.20–4.01) | 0.005 | 5 (2) | 1.76 (1.08–2.87) | 0.025 | 9 (4) | 2.86 (1.32–4.36) | 0.010 |
| Hsd3b1-03 | |||||||||
| A/A | 204 (86) | 1.00 (reference) | 23 (11) | 1.00 (reference) | 2 (1) | 1.00 (reference) | |||
| A/G | 26 (11) | 0.46 (0.14–1.52) | 0.203 | 186 (89) | 0.30 (0.17–0.56) | <0.001 | 248 (99) | 1.70 (0.42–6.91) | 0.460 |
| G/G | 6 (3) | 0.57 (0.20–1.62) | 0.295 | 0 (0) | - | ||||
| Hsd17b1-03 | |||||||||
| G/G | 84 (35) | 1.00 (reference) | 72 (33) | 1.00 (reference) | 82 (33) | 1.00 (reference) | |||
| G/A | 106 (44) | 0.61 (0.37–0.86) | 0.035 | 101 (46) | 0.81 (0.48–1.38) | 0.445 | 115 (46) | 0.67 (0.42–1.13) | 0.260 |
| A/A | 50 (21) | 0.64 (0.38–0.96) | 0.042 | 47 (21) | 0.46 (0.24–0.87) | 0.017 | 52 (21) | 0.51 (0.30–0.98) | 0.030 |
Values given in bold are statistically significant.
a
Adjusted for smoking status, pack-years, age, gender, race and tumor stage.
b
Approximately 20% of cases were missing DNA and were not included in the analysis.
c
Three of the 227 cases were missing DNA and were not included in the analysis.
d
Adjusted for smoking status, pack-years, age, gender and tumor stage.
e
Approximately 10% of the cases were missing DNA and were not included in the analysis.