Table II.

HRs of single SNPs and RCC survival

Gene	SNP	Allelesa	Minor allele frequency (dead/alive)	Best-fitting genetic model (All histology types)			Best-fitting genetic model (Clear cell carcinoma)
				Model	HR (95% CI)b	P-valuec	Model	HR (95% CI)b	P-value
Biogenesis pathway
DROSHA	rs6877842	G/C	0.15/0.16	DOM	0.79 (0.40–1.55)	0.494	DOM	0.91 (0.43–1.92)	0.811
	rs10719	C/T	0.26/0.26	DOM	0.68 (0.36–1.30)	0.246	DOM	0.59 (0.29–1.21)	0.151
DGCR8	rs417309	G/A	0.05/0.07	DOM	1.04 (0.42–2.54)	0.935	DOM	1.20 (0.48–2.99)	0.694
	rs3757	G/A	0.20/0.24	REC	0.44 (0.10–1.91)	0.273	DOM	0.91 (0.46–1.77)	0.771
	rs1640299	G/T	0.50/0.48	DOM	1.55 (0.82–2.95)	0.179	ADD	1.21 (0.77–1.89)	0.406
XPO5	rs11077	A/C	0.52/0.42	ADD	1.37 (0.91–2.05)	0.130	DOM	1.85 (0.89–3.83)	0.099
RAN	rs14035	C/T	0.29/0.28	ADD	1.25 (0.80–1.94)	0.324	REC	1.72 (0.62–4.79)	0.302
DICER	rs3742330	A/G	0.08/0.07	DOM	2.17 (0.98–4.79)	0.055	DOM	1.85 (0.78–4.39)	0.164
	rs13078	T/A	0.25/0.17	ADD	1.47 (0.96–2.27)	0.080	ADD	1.63 (0.98–2.72)	0.061
TRBP	rs784567	C/T	0.48/0.39	DOM	1.54 (0.79–2.99)	0.204	ADD	1.19 (0.79–1.80)	0.415
AGO1	rs636832	G/A	0.13/0.15	DOM	1.16 ( 0.58–2.29)	0.678	DOM	0.96 (0.43–2.11)	0.912
	rs595961	A/G	0.18/0.22	REC	1.63 (0.40–6.65)	0.494	ADD	0.88 (0.47–1.66)	0.699
AGO2	rs4961280	C/A	0.20/0.19	DOM	1.15 ( 0.63–2.10)	0.644	ADD	1.14 (0.66–1.96)	0.637
GEMIN4	rs910924	C/T	0.22/0.23	DOM	2.04 (1.11–3.76)	0.022	DOM	2.27 (1.13–4.57)	0.021
	rs2740348	G/C	0.16/0.15	DOM	1.59 (0.87–2.90)	0.132	DOM	1.39 (0.72–2.70)	0.325
	rs7813	T/C	0.37/0.36	ADD	1.74 (1.15–2.62)	0.009	ADD	1.71 (1.08–2.70)	0.021
	rs910925	G/C	0.37/0.37	ADD	1.74 (1.15–2.62)	0.009	ADD	1.71 (1.08–2.70)	0.021
	rs3744741	C/T	0.16/0.18	DOM	0.39 (0.19–0.77)	0.007	DOM	0.40 (0.18–0.85)	0.018
	rs1062923	T/C	0.19/0.16	DOM	0.75 (0.40–1.42)	0.379	DOM	0.83 (0.41–1.68)	0.604
	rs4968104	T/A	0.21/0.21	DOM	1.88 (1.03–3.42)	0.040	DOM	2.01 (1.02–3.98)	0.044
GEMIN3	rs197414	C/A	0.12/0.14	DOM	0.59 (0.30–1.17)	0.134	DOM	0.62 (0.30–1.26)	0.184
	rs197388	T/A	0.21/0.21	ADD	0.88 (0.54–1.43)	0.611	REC	0.28 (0.03–2.59)	0.259
	rs197412	T/C	0.40/0.45	ADD	0.70 (0.47–1.05)	0.087	ADD	0.62 (0.40–0.98)	0.041
HIWI	rs1106042	G/A	0.02/0.06	DOM	0.49 (0.11–2.12)	0.341	DOM	0.48 (0.11–2.10)	0.333
Pre-miRNA
mir146a	rs2910164	G/C	0.25/0.27	DOM	0.77 (0.43–1.40)	0.396	DOM	0.56 (0.29–1.08)	0.08
mir196a-2	rs11614913	C/T	0.34/0.37	REC	1.44 (0.66–3.16)	0.359	DOM	0.80 (0.43–1.50)	0.481
mir423	rs6505162	C/A	0.49/0.46	REC	0.95 (0.47–1.91)	0.886	REC	0.84 (0.39–1.81)	0.647
mir492	rs2289030	C/G	0.06/0.06	DOM	1.49 (0.58–3.82)	0.407	DOM	1.40 (0.51–3.87)	0.516
mir604	rs2368392	C/T	0.21/0.27	ADD	0.73 (0.43–1.24)	0.247	ADD	0.70 (0.40–1.23)	0.217
mir608	rs4919510	C/G	0.25/0.21	ADD	1.61 (1.00–2.57)	0.048	ADD	1.64 (0.96–2.79)	0.071
mir631	rs5745925	CT/—	0.10/0.09	DOM	0.77 (0.37–1.59)	0.481	DOM	0.65 (0.27–1.57)	0.335
Pri-miRNA
let7f-2	rs17276588	G/A	0.04/0.03	DOM	0.33 (0.09–1.15)	0.081	DOM	0.41 (0.12–1.47)	0.172
mir26a-1	rs7372209	C/T	0.37/0.28	DOM	1.51 (0.86–2.66)	0.154	DOM	1.33 (0.70–2.50)	0.384
mir30a	rs1358379	A/G	0.06/0.03	DOM	1.34 (0.59–3.07)	0.482	DOM	1.19 (0.45–3.17)	0.721
mir30c-1	rs16827546	C/T	0.02/0.04	DOM	0.26 (0.03–2.11)	0.208	N/A	N/A	N/A
mir100	rs1834306	C/T	0.47/0.46	REC	0.78 (0.38–1.59)	0.491	REC	0.81 (0.37–1.77)	0.597
mir124-1	rs531564	C/G	0.16/0.12	DOM	1.57 (0.85–2.88)	0.150	DOM	1.42 (0.72–2.81)	0.307
mir219-1	rs107822	G/A	0.20/0.26	DOM	0.75 (0.40–1.42)	0.380	ADD	0.70 (0.36–1.37)	0.296
	rs213210	T/C	0.06/0.07	DOM	0.88 (0.34–2.28)	0.790	DOM	0.70 (0.24–2.03)	0.511
mir373	rs12983273	C/T	0.15/0.14	DOM	1.75 (0.96–3.18)	0.066	DOM	2.04 (1.04–3.98)	0.038
	rs10425222	C/A	0.08/0.05	DOM	2.04 (0.89–4.68)	0.09	DOM	1.94 (0.67–5.62)	0.220

^aMajor/minor alleles.

^bAdjusted for age, sex, ethnicity, smoking status, stage, grade and treatments. P-value < 0.05 was in bold and used in the unfavorable genotype analysis.

^cUnderlined P-values remained significant after false discovery rate adjustment at 0.05 level.