Table III.

HRs of single SNPs and RCC recurrence

Gene	SNP	Allelesa	Minor allelle frequency (recurrence/no recurrence)	Best-fitting genetic model (All histology types)			Best-fitting genetic model (Clear cell carcinoma)
				Model	HR (95% CI)b	P-valuec	Model	HR (95% CI)b	P-value
Biogenesis pathway
DROSHA	rs6877842	G/C	0.13/0.14	DOM	0.52 (0.23–1.18)	0.118	DOM	0.36 (0.13–0.98)	0.046
	rs10719	C/T	0.21/0.26	ADD	0.61 (0.34–1.10)	0.102	ADD	0.63 (0.33–1.20)	0.161
DGCR8	rs417309	G/A	0.05/0.05	DOM	0.52 (0.17–1.65)	0.269	DOM	0.79 (0.24–2.55)	0.693
	rs3757	G/A	0.17/0.24	DOM	0.61 (0.30–1.22)	0.163	DOM	0.57 (0.25–1.30)	0.182
	rs1640299	G/T	0.45//0.51	DOM	0.95 (0.49–1.86)	0.889	DOM	0.86 (0.40–1.87)	0.708
XPO5	rs11077	A/C	0.45/0.44	DOM	0.57 (0.29–1.13)	0.109	DOM	0.36 (0.16–0.85)	0.020
RAN	rs14035	C/T	0.28/0.29	DOM	0.55 (0.27–1.11)	0.097	DOM	0.50 (0.23–1.09)	0.080
DICER	rs3742330	A/G	0.04/0.06	DOM	0.75 (0.23–2.45)	0.640	DOM	0.52 (0.13–2.04)	0.348
	rs13078	T/A	0.14/0.19	DOM	0.77 (0.39–1.55)	0.468	DOM	0.61 (0.26–1.41)	0.244
TRBP	rs784567	C/T	0.47/0.40	DOM	0.79 (0.37–1.68)	0.534	REC	1.31 (0.60–2.86)	0.493
AGO1	rs636832	G/A	0.10/0.15	DOM	0.82 (0.32–2.11)	0.680	DOM	0.69 (0.24–1.99)	0.497
	rs595961	A/G	0.16/0.22	REC	3.52 (0.88–14.02)	0.075	REC	3.65 (0.71–18.68)	0.120
AGO2	rs4961280	C/A	0.20/0.20	REC	2.74 (0.30–24.66)	0.369	DOM	0.62 (0.27–1.47)	0.280
GEMIN4	rs910924	C/T	0.26/0.23	DOM	1.53 (0.76–3.09)	0.234	DOM	1.27 (0.54–3.02)	0.585
	rs2740348	G/C	0.16/0.15	DOM	0.88 (0.42–1.84)	0.740	DOM	1.15 (0.50–2.64)	0.744
	rs7813	T/C	0.41/0.36	REC	1.69 (0.67–4.28)	0.268	ADD	1.38 (0.80–2.37)	0.246
	rs910925	G/C	0.41/0.36	REC	1.69 (0.67–4.28)	0.268	ADD	1.38 (0.80–2.37)	0.246
	rs3744741	C/T	0.16/0.17	DOM	0.62 (0.30–1.27)	0.190	DOM	0.67 (0.28–1.57)	0.354
	rs1062923	T/C	0.16/0.15	DOM	1.09 (0.50–2.38)	0.837	DOM	0.88 (0.33–2.35)	0.801
	rs4968104	T/A	0.23/0.21	DOM	1.63 (0.85–3.12)	0.144	DOM	1.30 (0.55–3.05)	0.546
GEMIN3	rs197414	C/A	0.12/0.13	DOM	0.72 (0.30–1.71)	0.46	REC	0.70 (0.28–1.74)	0.44
	rs197388	T/A	0.22/0.21	DOM	0.57 (0.28–1.15)	0.12	REC	0.43 (0.19–0.98)	0.05
	rs197412	T/C	0.42/0.44	REC	0.51 (0.21–1.24)	0.137	REC	0.39 (0.14–1.08)	0.069
HIWI	rs1106042	G/A	0.05/0.07	DOM	0.52 (0.15–1.74)	0.288	DOM	0.54 (0.16–1.84)	0.325
Pre-miRNA
mir146a	rs2910164	G/C	0.23/0.27	DOM	0.47 (0.24–0.92)	0.029	DOM	0.42 (0.19–0.90)	0.026
mir196a-2	rs11614913	C/T	0.34/0.38	DOM	0.37 (0.19–0.73)	0.004	DOM	0.29 (0.14–0.64)	0.002
mir423	rs6505162	C/A	0.43/0.48	REC	0.39 (0.17–0.89)	0.026	REC	0.46 (0.19–1.13)	0.091
mir492	rs2289030	C/G	0.06/0.08	DOM	0.79 (0.25–2.48)	0.692	DOM	0.58 (0.13–2.62)	0.476
mir604	rs2368392	C/T	0.22/0.28	REC	0.27 (0.04–1.99)	0.197	REC	0.28 (0.04–2.16)	0.223
mir608	rs4919510	C/G	0.29/0.22	ADD	1.88 (1.12–3.16)	0.017	ADD	2.21 (1.24–3.92)	0.007
mir631	rs5745925	CT/—	0.11/0.08	DOM	3.93 (1.69–9.17)	0.002	DOM	4.62 (1.72–12.40)	0.002
Pri-miRNA
let7f-2	rs17276588	G/A	0.05/0.03	DOM	1.05 (0.32–3.43)	0.929	DOM	1.43 (0.41–4.98)	0.573
mir26a-1	rs7372209	C/T	0.26/0.29	DOM	0.84 (0.43–1.65)	0.622	ADD	0.67 (0.33–1.37)	0.274
mir30a	rs1358379	A/G	0.06/0.03	DOM	1.36 (0.44–4.18)	0.595	DOM	1.41 (0.36–5.56)	0.620
mir30c-1	rs16827546	C/T	0.00/0.04	N/A	N/A	N/A	N/A	N/A	N/A
mir100	rs1834306	C/T	0.40/0.49	REC	0.51 (0.21–1.24)	0.139	REC	0.53 (0.20–1.42)	0.206
mir124-1	rs531564	C/G	0.13/0.11	DOM	1.83 (0.83–4.07)	0.136	DOM	1.95 (0.83–4.59)	0.127
mir219-1	rs107822	G/A	0.27/0.27	DOM	1.85 (0.89–3.83)	0.097	DOM	2.18 (0.94–5.09)	0.071
	rs213210	T/C	0.08/0.07	DOM	1.47 (0.60–3.59)	0.401	DOM	1.47 (0.56–3.85)	0.433
mir373	rs12983273	C/T	0.14/0.14	DOM	1.68 (0.80–3.53)	0.174	DOM	1.23 (0.52–2.87)	0.640
	rs10425222	C/A	0.06/0.05	DOM	1.84 (0.64–5.27)	0.258	DOM	2.39 (0.69–8.26)	0.168

^aMajor/minor alleles.

^bAdjusted for age, sex, ethnicity, smoking status, stage, grade and treatments. P-value < 0.05 was in bold and used in the unfavorable genotype analysis.

^cUnderlined P-values remained significant after false discovery rate adjustment at 0.05 level.