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Effects of the SK inhibitor ABC294640 (50 mg/kg dose) on Sph levels in colons of animals in the AOM + DSS mouse model of colitis. Colon samples from mice described in Table I were extracted and assayed for levels of Sph by liquid chromatography-tandem mass spectroscopy as described in the ‘Materials and Methods’ section. Values represent the mean ± standard error for five samples per group.
