Table I.
Macroscopic lesion incidence and multiplicity in mice treated with AOM/DSS ± ABC294640
| Group | n | Percentage of animals with macroscopic lesions (incidence) | Number of macroscopic lesions per animal (multiplicity), mean ± SE | Percentage of macroscopic lesions > 5 mm2 |
| Vehicle (PEG400) | 10 | 0.0 | 0 | 0 |
| AOM + vehicle (PEG400) | 10 | 0.0 | 0 | 0 |
| DSS + vehicle (PEG400) | 10 | 10.0 | 1 ± 0 | 0 |
| Vehicle + ABC294640 (50 mg/kg) | 10 | 0.0 | 0 | 0 |
| AOM + ABC294640 (50 mg/kg) | 10 | 10.0 | 2 ± 0 | 0 |
| AOM + DSS + vehicle (PEG400) | 10 | 92.3 | 4.9 ± 1.1 | 32 |
| AOM + DSS + ABC294640 (20 mg/kg) | 10 | 70.0 | 2.4 ± 1.0 | 25 |
| AOM + DSS + ABC294640 (50 mg/kg) | 10 | 50.0a | 1.6 ± 0.7a | 13 |
a
Indicates significant difference from AOM + DSS-treated group (see Materials and Methods for statistics).