Table II.
Histological tumor incidence and multiplicity in mice treated with AOM/DSS ± ABC294640
| Group | n | Percentage of animals with colon tumors (incidence) | Number of tumors per animal (multiplicity) mean ± SE |
| Vehicle (PEG400) | 10 | 0.0 | 0 |
| AOM + vehicle (PEG400) | 10 | 0.0 | 0 |
| DSS + vehicle (PEG400) | 10 | 10.0 | 2 ± 0 |
| Vehicle + ABC294640 (50 mg/kg) | 10 | 0.0 | 0 |
| AOM + ABC294640 (50 mg/kg) | 10 | 0.0 | 0 |
| AOM + DSS + vehicle (PEG400) | 10 | 80.0 | 2.1 ± 0.23 |
| AOM + DSS + ABC294640 (20 mg/kg) | 10 | 40.0a | 1.2 ± 0a |
| AOM + DSS + ABC294640 (50 mg/kg) | 10 | 30.0a | 0.8 ± 0.4a |
a
Indicates significant difference from AOM + DSS-treated group (see Materials and Methods for statistics).